PRP/GFC

PRP/GFC

PRP- Platelet Rich Plasma

GFC-Growth Factor Concentrate

1. A newer modality aiming to promote tissue regeneration.
2. The use of PRP/ GFC injections has recently become more prevalent in treating orthopaedic conditions more so in sports injuries.
3. Current evidence suggests that PRP/ GFC injections are relatively safe and can potentially accelerate the soft tissue healing process.
4. The goal is to facilitate regeneration of injured tissue such that it regains capability of attaining the mechanical performance and functionality of non-injured tissue.

 

How to obtain PRP/GFC

1. A sample of whole blood usually contains 93 % red blood cells, 6 % platelets and 1 % white cells (leukocytes).
2. Red blood cells are not useful in the healing process, thus separating them and increasing platelets and leukocytes concentration to 94 %, stimulates tissue regeneration.
3. Platelet-rich plasma (PRP) is obtained by a process, which require differential centrifugation of the whole blood.

 

How does PRP/GFC acts

1. The reason behind PRP:  Platelets are the first to arrive at the site of tissue injury, and release release growth factors that play a critical role in tissue healing.
2. Many of the cytokines and growth factors believed to be responsible for the effects of PRP are contained within the α-granules of platelets. Platelet activation triggers degranulation and release of these growth factors.
3. Some available kits allow activation of platelet in withdrawn blood, thus permitting injection of  these growth factors (GFC).

Procedure Protocol

1. Procure whole blood (20-30 ml in PRP, 4ml in GFC) in vacutainer.
2. Follow procedure to extract PRP/GFC.
3. Prepare injection site and inject PRP/GFC at site of disease.
4. Usually, 3 injections at 1 month interval is followed.
5. Give rest to affected limb as adviced.